RBO Aleph, is a novel server for fully automated protein structure prediction developed at the Robotics and Biology Lab (RBO), Technische Universität Berlin. The server implements template-based modeling, protein contact prediction, and ab initio structure prediction.
It provides an intuitive interface to our protein structure prediction pipeline that is particularly easy-to-use also for non-expert users. The server automatically picks the most promising modeling method, template-based modeling or ab initio structure prediction, based on template availability. The user can analyze the prediction results directly in the web brower. The particular strength of RBO Aleph is the state-of-the-art ab initio prediction of hard protein targets for which templates cannot be detected.

RBO Aleph ranked among the top servers in the recent CASP11 experiment in the template-free structure prediction category. In addition, RBO Aleph’s performance is continuously monitored in CAMEO.


drawing.pngdrawing.pngThis website is free for academic users only, commercial entities are required to obtain a license for the use of Rosetta here: https://els.comotion.uw.edu/express_license_technologies/rosetta


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The development of RBO_Aleph server is supported by the Alexander von Humboldt professorship – awarded by the Alexander von Humboldt foundation and funded through the Ministry of Education and Research, BMBF,
July 2009 – June 2015

Contact information

Please send us question, feedback, and comments to rbo.aleph@robotics.tu-berlin.de.

Technische Universität Berlin
Robotics and Biology Laboratory (RBO)
Prof. Oliver Brock
Sekr. MAR 5-1
D-10587 Berlin